Zindzi was Nelson Mandela’s sixth child and his second with Winnie Madikizela-Mandela, his second wife
She died in a Johannesburg hospital in the early hours of Monday morning, public broadcaster SABC said.
Till her death, she was the South African ambassador to Denmark.
“This is untimely. She still had a role to play in the transformation of our own society and a bigger role to play even in the African National Congress (ANC),” said ANC spokesman Pule Mabe.
Minister of International Relations Naledi Pandor said: “Zindzi will not only be remembered as a daughter of our struggle heroes, but as a struggle heroine in her own right.”
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